Defibrotide
Basic Information
| Item | Value |
|---|---|
| DrugBank ID | DB04932 |
| Evidence Level | L5 (Computational Prediction) |
| Number of Predicted Indications | 86 |
Predicted Indications (TxGNN)
The following are potential new indications predicted by the TxGNN model. Higher scores indicate higher predicted relevance.
| # | Indication | Source |
|---|---|---|
| 1 | pseudo-von Willebrand disease | KG + DL |
| 2 | primary release disorder of platelets | KG + DL |
| 3 | Glanzmann thrombasthenia | KG + DL |
| 4 | thrombotic thrombocytopenic purpura | KG + DL |
| 5 | Scott syndrome | KG + DL |
| 6 | bleeding diathesis due to a collagen receptor defect | KG + DL |
| 7 | hemorrhagic disorder due to a constitutional thrombocytopenia | KG + DL |
| 8 | congenital factor V deficiency | KG + DL |
| 9 | fetal and neonatal alloimmune thrombocytopenia | KG + DL |
| 10 | thrombocytopenic purpura | KG + DL |
| 11 | inherited thrombophilia | KG + DL |
| 12 | hepatic infarction | KG + DL |
| 13 | peliosis hepatis | KG + DL |
| 14 | familial apolipoprotein C-II deficiency | KG + DL |
| 15 | syndrome with combined immunodeficiency | KG + DL |
| 16 | platelet-type bleeding disorder | KG + DL |
| 17 | Ehlers-Danlos syndrome, fibronectinemic type | KG + DL |
| 18 | flood factor deficiency | KG + DL |
| 19 | methylcobalamin deficiency type cblG | KG + DL |
| 20 | Von Willebrand disease, X-linked form | KG + DL |
| 21 | hereditary thrombocytosis with transverse limb defect | KG + DL |
| 22 | familial thrombomodulin anomalies | KG + DL |
| 23 | hemophilia | KG + DL |
| 24 | atypical hemolytic-uremic syndrome with thrombomodulin anomaly | KG + DL |
| 25 | neuropathy, painful | KG + DL |
| 26 | von Willebrand disease | KG + DL |
| 27 | acquired coagulation factor deficiency | KG + DL |
| 28 | adenosine deaminase deficiency | KG + DL |
| 29 | reticular dysgenesis | KG + DL |
| 30 | congenital factor XIII deficiency | KG + DL |
| 31 | autosomal dominant macrothrombocytopenia | KG + DL |
| 32 | pancytopenia due to IKZF1 mutations | KG + DL |
| 33 | combined immunodeficiency due to CRAC channel dysfunction | KG + DL |
| 34 | severe combined immunodeficiency due to LCK deficiency | KG + DL |
| 35 | factor XIII, A subunit, deficiency | KG + DL |
| 36 | lipase deficiency, combined | KG + DL |
| 37 | absent thumb-short stature-immunodeficiency syndrome | KG + DL |
| 38 | facial dysmorphism-immunodeficiency-livedo-short stature syndrome | KG + DL |
| 39 | liver angiosarcoma | KG + DL |
| 40 | esophageal varices with bleeding | KG + DL |
| 41 | esophageal varices without bleeding | KG + DL |
| 42 | congenital factor XI deficiency | KG + DL |
| 43 | inherited prekallikrein deficiency | KG + DL |
| 44 | heparin cofactor 2 deficiency | KG + DL |
| 45 | immuno-osseous dysplasia | KG + DL |
| 46 | thrombophilia due to protein S deficiency, autosomal dominant | KG + DL |
| 47 | autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis | KG + DL |
| 48 | autosomal dominant familial periodic fever | KG + DL |
| 49 | varicose disease | KG + DL |
| 50 | primary immunodeficiency due to a defect in adaptive immunity | KG + DL |
(Showing top 50 of 86 predictions)
Disclaimer
These predictions are for research purposes only and do not constitute medical advice. Clinical validation is required before any clinical application.