Ivacaftor
Basic Information
| Item | Value |
|---|---|
| DrugBank ID | DB08820 |
| Evidence Level | L5 (Computational Prediction) |
| Number of Predicted Indications | 65 |
Predicted Indications (TxGNN)
The following are potential new indications predicted by the TxGNN model. Higher scores indicate higher predicted relevance.
| # | Indication | Source |
|---|---|---|
| 1 | rheumatoid arthritis | KG + DL |
| 2 | HIV infectious disease | KG + DL |
| 3 | leprosy | KG + DL |
| 4 | simian immunodeficiency virus infection | KG + DL |
| 5 | feline acquired immunodeficiency syndrome | KG + DL |
| 6 | multiple endocrine neoplasia | KG + DL |
| 7 | neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter | KG + DL |
| 8 | brachydactyly-syndactyly syndrome | KG + DL |
| 9 | colobomatous microphthalmia-rhizomelic dysplasia syndrome | KG + DL |
| 10 | cytomegalovirus infection | KG + DL |
| 11 | homozygous familial hypercholesterolemia | KG + DL |
| 12 | malignant catarrh | KG + DL |
| 13 | infectious bovine rhinotracheitis | KG + DL |
| 14 | hereditary thrombocytopenia with normal platelets | KG + DL |
| 15 | marcothrombocytopenia with mitral valve insufficiency | KG + DL |
| 16 | transient neonatal thrombocytopenia | KG + DL |
| 17 | thrombocytopenia | KG + DL |
| 18 | gout | KG + DL |
| 19 | systemic mastocytosis | KG + DL |
| 20 | dense granule disease | KG + DL |
| 21 | amyotrophic lateral sclerosis | KG + DL |
| 22 | echinococcus granulosus infectious disease | KG + DL |
| 23 | Smouldering systemic mastocytosis | KG + DL |
| 24 | Mills syndrome | KG + DL |
| 25 | amyotrohpic lateral sclerosis type 22 | KG + DL |
| 26 | lymphoadenopathic mastocytosis with eosinophilia | KG + DL |
| 27 | amyotrophic lateral sclerosis, susceptibility to | KG + DL |
| 28 | fibroma of prostate | KG + DL |
| 29 | female breast carcinoma | KG + DL |
| 30 | benign reproductive system neoplasm | KG + DL |
| 31 | Brenner tumor | KG + DL |
| 32 | dermatofibrosarcoma protuberans | KG + DL |
| 33 | migraine disorder | KG + DL |
| 34 | HER2 positive breast carcinoma | KG + DL |
| 35 | migraine with brainstem aura | KG + DL |
| 36 | axial spondylometaphyseal dysplasia | KG + DL |
| 37 | benign prostate phyllodes tumor | KG + DL |
| 38 | hypoalphalipoproteinemia | KG + DL |
| 39 | kyphoscoliotic heart disease | KG + DL |
| 40 | oral candidiasis | KG + DL |
| 41 | pulmonary hypertension | KG + DL |
| 42 | acne (disease) | KG + DL |
| 43 | male reproductive organ cancer | KG + DL |
| 44 | commissural lip fistula | KG + DL |
| 45 | prostate leiomyoma | KG + DL |
| 46 | osteoradionecrosis of the mandible | KG + DL |
| 47 | oral leukoedema | KG + DL |
| 48 | burning mouth syndrome | KG + DL |
| 49 | bilateral parasagittal parieto-occipital polymicrogyria | KG + DL |
| 50 | trichomegaly-retina pigmentary degeneration-dwarfism syndrome | KG + DL |
(Showing top 50 of 65 predictions)
Disclaimer
These predictions are for research purposes only and do not constitute medical advice. Clinical validation is required before any clinical application.