Asfotase Alfa
Basic Information
| Item | Value |
|---|---|
| DrugBank ID | DB09105 |
| Evidence Level | L5 (Computational Prediction) |
| Number of Predicted Indications | 100 |
Predicted Indications (TxGNN)
The following are potential new indications predicted by the TxGNN model. Higher scores indicate higher predicted relevance.
| # | Indication | Source |
|---|---|---|
| 1 | mitochondrial oxidative phosphorylation disorder due to nuclear DNA anomalies | KG + DL |
| 2 | Steel syndrome | KG + DL |
| 3 | exocrine pancreatic insufficiency | KG + DL |
| 4 | Scheie syndrome | KG + DL |
| 5 | Hurler syndrome | KG + DL |
| 6 | lysosomal storage disease with skeletal involvement | KG + DL |
| 7 | familial apolipoprotein C-II deficiency | KG + DL |
| 8 | esophageal varices without bleeding | KG + DL |
| 9 | esophageal varices with bleeding | KG + DL |
| 10 | cystinosis | KG + DL |
| 11 | primary bone dysplasia | KG + DL |
| 12 | lysosomal disease with hypertrophic cardiomyopathy | KG + DL |
| 13 | syndromic neurometabolic disease with X-linked intellectual disability | KG + DL |
| 14 | eyelids malposition disorder | KG + DL |
| 15 | varicose disease | KG + DL |
| 16 | growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant | KG + DL |
| 17 | monosomy X | KG + DL |
| 18 | primary bone dysplasia with increased bone density | KG + DL |
| 19 | Sanfilippo syndrome | KG + DL |
| 20 | Hurler-Scheie syndrome | KG + DL |
| 21 | cytochrome-c oxidase deficiency disease | KG + DL |
| 22 | developmental anomaly of metabolic origin | KG + DL |
| 23 | Arts syndrome | KG + DL |
| 24 | Charcot-Marie-Tooth disease | KG + DL |
| 25 | reticular dysgenesis | KG + DL |
| 26 | lipase deficiency, combined | KG + DL |
| 27 | perinatal lethal hypophosphatasia | KG + DL |
| 28 | neurometabolic disease | KG + DL |
| 29 | inborn disorder of lysosomal amino acid transport | KG + DL |
| 30 | adenosine deaminase deficiency | KG + DL |
| 31 | glycogen storage disease due to GLUT2 deficiency | KG + DL |
| 32 | ocular cystinosis | KG + DL |
| 33 | severe combined immunodeficiency due to LCK deficiency | KG + DL |
| 34 | sterol biosynthesis disorder | KG + DL |
| 35 | Immunoerythromyeloid hypoplasia | KG + DL |
| 36 | camptodactyly, myopia, and fibrosis of the medial rectus muscle of eye | KG + DL |
| 37 | congenital ectropion | KG + DL |
| 38 | ptosis-vocal cord paralysis syndrome | KG + DL |
| 39 | ptosis-strabismus-ectopic pupils syndrome | KG + DL |
| 40 | congenital entropion | KG + DL |
| 41 | congenital Horner syndrome (disease) | KG + DL |
| 42 | Astley-Kendall dysplasia | KG + DL |
| 43 | jaw-winking syndrome | KG + DL |
| 44 | chondrodysplasia punctata, tibial-metacarpal type | KG + DL |
| 45 | ptosis-upper ocular movement limitation-absence of lacrimal punctum syndrome | KG + DL |
| 46 | mucopolysaccharidosis | KG + DL |
| 47 | epiblepharon | KG + DL |
| 48 | familial lipoprotein lipase deficiency | KG + DL |
| 49 | proximal myopathy with extrapyramidal signs | KG + DL |
| 50 | benign neoplasm of adrenal gland | KG + DL |
(Showing top 50 of 100 predictions)
Disclaimer
These predictions are for research purposes only and do not constitute medical advice. Clinical validation is required before any clinical application.