Tezacaftor
Basic Information
| Item | Value |
|---|---|
| DrugBank ID | DB11712 |
| Evidence Level | L5 (Computational Prediction) |
| Number of Predicted Indications | 100 |
Predicted Indications (TxGNN)
The following are potential new indications predicted by the TxGNN model. Higher scores indicate higher predicted relevance.
| # | Indication | Source |
|---|---|---|
| 1 | HIV infectious disease | KG + DL |
| 2 | leprosy | KG + DL |
| 3 | multiple endocrine neoplasia | KG + DL |
| 4 | simian immunodeficiency virus infection | KG + DL |
| 5 | feline acquired immunodeficiency syndrome | KG + DL |
| 6 | neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter | KG + DL |
| 7 | rheumatoid arthritis | KG + DL |
| 8 | female breast carcinoma | KG + DL |
| 9 | homozygous familial hypercholesterolemia | KG + DL |
| 10 | amyotrophic lateral sclerosis | KG + DL |
| 11 | thrombocytopenia | KG + DL |
| 12 | hereditary thrombocytopenia with normal platelets | KG + DL |
| 13 | marcothrombocytopenia with mitral valve insufficiency | KG + DL |
| 14 | brachydactyly-syndactyly syndrome | KG + DL |
| 15 | transient neonatal thrombocytopenia | KG + DL |
| 16 | oral candidiasis | KG + DL |
| 17 | collagenopathy | KG + DL |
| 18 | dense granule disease | KG + DL |
| 19 | Mills syndrome | KG + DL |
| 20 | amyotrohpic lateral sclerosis type 22 | KG + DL |
| 21 | lymphocytic hypereosinophilic syndrome | KG + DL |
| 22 | amyotrophic lateral sclerosis, susceptibility to | KG + DL |
| 23 | Prinzmetal angina | KG + DL |
| 24 | cytomegalovirus infection | KG + DL |
| 25 | axial spondylometaphyseal dysplasia | KG + DL |
| 26 | cerebral infarction | KG + DL |
| 27 | colobomatous microphthalmia-rhizomelic dysplasia syndrome | KG + DL |
| 28 | pulmonary hypertension | KG + DL |
| 29 | trichomegaly-retina pigmentary degeneration-dwarfism syndrome | KG + DL |
| 30 | lethal arthrogryposis-anterior horn cell disease syndrome | KG + DL |
| 31 | bilateral parasagittal parieto-occipital polymicrogyria | KG + DL |
| 32 | coronary artery disease | KG + DL |
| 33 | commissural lip fistula | KG + DL |
| 34 | osteoradionecrosis of the mandible | KG + DL |
| 35 | candidiasis | KG + DL |
| 36 | oral leukoedema | KG + DL |
| 37 | burning mouth syndrome | KG + DL |
| 38 | lower motor neuron syndrome with late-adult onset | KG + DL |
| 39 | kyphoscoliotic heart disease | KG + DL |
| 40 | monomelic amyotrophy | KG + DL |
| 41 | obsolete familial combined hyperlipidemia | KG + DL |
| 42 | fibroma of prostate | KG + DL |
| 43 | benign reproductive system neoplasm | KG + DL |
| 44 | Brenner tumor | KG + DL |
| 45 | infectious bovine rhinotracheitis | KG + DL |
| 46 | malignant catarrh | KG + DL |
| 47 | echinococcus granulosus infectious disease | KG + DL |
| 48 | dermatofibrosarcoma protuberans | KG + DL |
| 49 | HER2 positive breast carcinoma | KG + DL |
| 50 | neuroblastoma | KG + DL |
(Showing top 50 of 100 predictions)
Disclaimer
These predictions are for research purposes only and do not constitute medical advice. Clinical validation is required before any clinical application.