Elexacaftor
Basic Information
| Item | Value |
|---|---|
| DrugBank ID | DB15444 |
| Evidence Level | L5 (Computational Prediction) |
| Number of Predicted Indications | 100 |
Predicted Indications (TxGNN)
The following are potential new indications predicted by the TxGNN model. Higher scores indicate higher predicted relevance.
| # | Indication | Source |
|---|---|---|
| 1 | rheumatoid arthritis | KG + DL |
| 2 | amyotrophic lateral sclerosis | KG + DL |
| 3 | leprosy | KG + DL |
| 4 | multiple endocrine neoplasia | KG + DL |
| 5 | Mills syndrome | KG + DL |
| 6 | amyotrophic lateral sclerosis, susceptibility to | KG + DL |
| 7 | amyotrohpic lateral sclerosis type 22 | KG + DL |
| 8 | migraine with or without aura, susceptibility to | KG + DL |
| 9 | nephrogenic syndrome of inappropriate antidiuresis | KG + DL |
| 10 | pulmonary hypertension | KG + DL |
| 11 | axial spondylometaphyseal dysplasia | KG + DL |
| 12 | brachydactyly-syndactyly syndrome | KG + DL |
| 13 | bilateral parasagittal parieto-occipital polymicrogyria | KG + DL |
| 14 | migraine disorder | KG + DL |
| 15 | kyphoscoliotic heart disease | KG + DL |
| 16 | homozygous familial hypercholesterolemia | KG + DL |
| 17 | trichomegaly-retina pigmentary degeneration-dwarfism syndrome | KG + DL |
| 18 | lethal arthrogryposis-anterior horn cell disease syndrome | KG + DL |
| 19 | female breast carcinoma | KG + DL |
| 20 | monomelic amyotrophy | KG + DL |
| 21 | lower motor neuron syndrome with late-adult onset | KG + DL |
| 22 | migraine with brainstem aura | KG + DL |
| 23 | colobomatous microphthalmia-rhizomelic dysplasia syndrome | KG + DL |
| 24 | coronary artery disease | KG + DL |
| 25 | autosomal dominant mitochondrial myopathy with exercise intolerance | KG + DL |
| 26 | HIV infectious disease | KG + DL |
| 27 | hyperthyroidism | KG + DL |
| 28 | Prinzmetal angina | KG + DL |
| 29 | thrombocytopenia | KG + DL |
| 30 | resistance to thyroid hormone due to a mutation in thyroid hormone receptor beta | KG + DL |
| 31 | marcothrombocytopenia with mitral valve insufficiency | KG + DL |
| 32 | hereditary thrombocytopenia with normal platelets | KG + DL |
| 33 | anomalous left coronary artery from the pulmonary artery | KG + DL |
| 34 | transient neonatal thrombocytopenia | KG + DL |
| 35 | heart disease | KG + DL |
| 36 | simian immunodeficiency virus infection | KG + DL |
| 37 | feline acquired immunodeficiency syndrome | KG + DL |
| 38 | Laubry-Pezzi syndrome | KG + DL |
| 39 | dense granule disease | KG + DL |
| 40 | Pierre Robin syndrome associated with a chromosomal anomaly | KG + DL |
| 41 | Jeune syndrome situs inversus | KG + DL |
| 42 | atrophoderma vermiculata | KG + DL |
| 43 | genetic syndromic Pierre Robin syndrome | KG + DL |
| 44 | interventricular septum aneurysm | KG + DL |
| 45 | partial deletion of the long arm of chromosome 7 | KG + DL |
| 46 | arteriosclerosis disorder | KG + DL |
| 47 | disorder of fucoglycosan synthesis | KG + DL |
| 48 | orofacial clefting syndrome | KG + DL |
| 49 | partial deletion of the long arm of chromosome 22 | KG + DL |
| 50 | myocardial ischemia | KG + DL |
(Showing top 50 of 100 predictions)
Disclaimer
These predictions are for research purposes only and do not constitute medical advice. Clinical validation is required before any clinical application.