Diltiazem

Evidence Level: N/A

Predicted Indications: 0

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Table of Contents

1. Diltiazem
   1. Pharmacist Assessment Report
   2. Diltiazem: Known uses and market status in Canada
   3. Summary
   4. Quick overview
   5. Known uses among the model’s candidates
      1. Approved (supported by a licence or label)
      2. Related to an approved indication (same disease category)
      3. Relations recorded in the knowledge graph (no approval found)
   6. Canada Market Information
   7. Safety Considerations
   8. Disclaimer

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Pharmacist Assessment Report

Diltiazem: Known uses and market status in Canada

Summary

The TxGNN deep-learning model (score ≥ 0.99) produced candidates for Diltiazem, but every candidate that can be traced to a source is already a known use. There is therefore currently no new predicted indication for this drug.

Quick overview

Item	Content
New predicted indications	None (all traceable model candidates are known uses)
Known uses among model candidates	1
Evidence level	Not applicable
Canada Market Status	Marketed (marketed DINs on record: at least 18; dormant: 2)
Number of DINs	at least 20

Known uses among the model’s candidates

Approved (supported by a licence or label)

Indication	Source
Prinzmetal angina	Licence in another country (approved indication: angina)

Related to an approved indication (same disease category)

Indication	Approved category
none	none

Relations recorded in the knowledge graph (no approval found)

Indication
none

Canada Market Information

Licence	Product	Dosage form	Status
02528061	JAMP DILTIAZEM CD		Valid
02546450	M-DILTIAZEM T		Valid
02271656	TEVA-DILTIAZEM HCL ER		DORMANT
02370492	TEVA-DILTIAZEM T		Valid
02256770	TIAZAC XC		Valid
02256738	TIAZAC XC		Valid
02230997	APO-DILTIAZ CD		Valid
02229526	APO-DILTIAZ CD		Valid
02400456	DILTIAZEM CD		Valid
02429330	TEVA-DILTIAZEM XC		Valid
02231150	TIAZAC		Valid
02540924	PRO-DILTIAZEM CD		Valid
02231151	TIAZAC		Valid
02271605	TEVA-DILTIAZEM HCL ER		DORMANT
02516136	DILTIAZEM T		Valid
02484080	MAR-DILTIAZEM CD		Valid
02242541	TEVA-DILTIAZEM CD		Valid
00771384	AA-DILTIAZ		Valid
02256762	TIAZAC XC		Valid
02400421	DILTIAZEM CD		Valid

Only part of the licence list is held in the data; the list may be incomplete.

Safety Considerations

• Contraindications flagged in the knowledge graph (not label text): Several disease associations are recorded, including:
  • Cardiac conduction and rhythm: atrioventricular block, sick sinus syndrome, Wolff-Parkinson-White syndrome, Lown-Ganong-Levine syndrome, ventricular tachycardia
  • Structural and haemodynamic: aortic stenosis, hypertrophic cardiomyopathy, hypotensive disorder, renal artery obstruction
  • Blood: neutropenia, agranulocytosis
  • Angioedema (several forms)
  • Organ disease: kidney disease, liver disease, gallbladder disease
  • Other: connective tissue, bone and cartilage disease

  These are database associations and must be verified against the official label.

• Drug Interactions: 100 interactions were recorded. The only one rated Major in the sample is loperamide. Moderate-level interactions include:
  • Corticosteroids: hydrocortisone, dexamethasone, betamethasone, budesonide, triamcinolone
  • Other drugs: pioglitazone, canagliflozin, bupropion, aprepitant, morphine, acetylsalicylic acid
  • Calcium salts: carbonate, chloride, citrate, acetate and others

Label warnings and contraindications from the Health Canada package insert are not available, so please refer to the package insert for authoritative safety information.

Disclaimer

This content is for research purposes only and does not constitute medical advice. Clinical validation is required before any clinical application.

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