Pilocarpine
| Evidence Level: N/A | Predicted Indications: 0 |
Table of Contents
- Pilocarpine
Pilocarpine: Known uses and market status in Canada
Summary
The TxGNN deep-learning model produced candidates for Pilocarpine, but every candidate that can be traced to a source is already a known use. There is therefore currently no new predicted indication for this drug in Canada. The one known use among the candidates is primary hereditary glaucoma, which is supported by a licence in another country.
Quick overview
| Item | Content |
|---|---|
| New predicted indications | None (all traceable model candidates are known uses) |
| Known uses among model candidates | 1 |
| Evidence level | Not applicable |
| Canada Market Status | Marketed (marketed DINs: 5 of 5) |
| Number of DINs | 5 (marketed: 5) |
Known uses among the model’s candidates
Approved (supported by a licence or label)
| Indication | Source |
|---|---|
| primary hereditary glaucoma | licence in another country (approved indication: glaucoma) |
Related to an approved indication (same disease category)
| Indication | Approved category |
|---|---|
| none | none |
Relations recorded in the knowledge graph (no approval found)
| Indication |
|---|
| none |
Canada Market Information
| Licence | Product | Dosage form | Status |
|---|---|---|---|
| 00000868 | ISOPTO CARPINE | Valid | |
| 02496119 | M-PILOCARPINE | Valid | |
| 02148463 | MINIMS PILOCARPINE NITRATE | Valid | |
| 02216345 | SALAGEN | Valid | |
| 02509571 | JAMP PILOCARPINE | Valid |
Safety Considerations
- Disease-related cautions (from knowledge-graph contraindication links, not label text):
- Eye conditions: angle-closure (closed-angle) glaucoma, keratitis, keratoconjunctivitis, iritis, iridocyclitis, uveitis, retinal detachment
- Respiratory conditions: asthma, chronic obstructive pulmonary disease, bronchial disease
- Biliary and liver conditions: cholelithiasis, cholecystolithiasis, choledocholithiasis, cholecystitis, biliary tract disease, obstructive jaundice, liver failure
- Kidney conditions: nephrolithiasis, acute urate nephropathy
- Drug Interactions: The interaction search returned 100 records. The ones listed as Moderate are mainly anticholinergic (antimuscarinic) agents, which may oppose pilocarpine’s effect: hyoscyamine, atropine (including ophthalmic), glycopyrronium (including topical), clidinium, dicyclomine, mepenzolate, methscopolamine, propantheline, scopolamine (including ophthalmic) and trospium. Several others (e.g., pantoprazole, omeprazole, lansoprazole, clotrimazole, morphine, metformin, epinephrine) are listed with an unknown severity level.
Please refer to the package insert for official warnings and contraindications.
Disclaimer
This content is for research purposes only and does not constitute medical advice. Clinical validation is required before any clinical application.